Potential of pre-contrast T1 mapping as a marker of interstitial fibrosis in severe aortic stenosis
نویسندگان
چکیده
Potential of pre-contrast T1 mapping as a marker of interstitial fibrosis in severe aortic stenosis Andrew Jabbour, Tevfik F Ismail, Callum Ettles, Carl Shakespeare, Sameer Zaman, Oluwatosin Sotubo, Saman S Zaman, Benjamin Hewins, Rick Wage, Ankur Gulati, Pedro F Ferreira, Pierre Croisille, Yanqiu Feng, Raad H Mohiaddin, Taigang He, John Pepper, David N Firmin, Dudley J Pennell, Mario Petrou, Sanjay K Prasad
منابع مشابه
Histological Validation of measurement of diffuse interstitial myocardial fibrosis by myocardial extravascular volume fraction from Modified Look-Locker imaging (MOLLI) T1 mapping at 3 T
BACKGROUND Gadolinium (Gd) Extracellular volume fraction (ECV) by Cardiovascular Magnetic Resonance (CMR) has been proposed as a non-invasive method for assessment of diffuse myocardial fibrosis. Yet only few studies used 3 T CMR to measure ECV, and the accuracy of ECV measurements at 3 T has not been established. Therefore the aims of the present study were to validate measurement of ECV by MO...
متن کاملBolus administration T1 mapping as a marker of interstitial myocardial fibrosis in severe aortic stenosis
Background Aortic stenosis (AS) is associated with increased interstitial myocardial fibrosis (IMF). This is detectable by cardiovascular magnetic resonance (CMR) after gadolinium infusion. T1-mapping-derived partition coefficients (l) and extracellular volume fractions (Ve) have also been shown to correlate with IMF after a simple bolus administration of gadolinium. We hypothesized that the l ...
متن کاملPre- and post-contrast T1 mapping for detection of myocardial fibrosis in severe aortic stenosis before and after aortic valve replacement
Background Severe aortic stenosis (AS) leads to diffuse fibrosis in the myocardium, which could cause poor clinical outcome. Cardiovascular Magnetic Resonance (CMR) with recently T1 mapping is a promising technique to identify diffuse myocardial fibrosis. The Objective of the present study was to assess myocardial fibrosis by CMR using T1 mapping in patients with surgical AS and evaluate the ev...
متن کاملT1 values by conservative septal postprocessing approach are superior in relating to the interstitial myocardial fibrosis: findings from patients with severe aortic stenosis
Background Accumulation of diffuse interstitial myocardial fibrosis in severe aortic stenosis relates to left ventricular (LV) functional impairment and determines the postoperative outcome in these patients. T1 mapping has been proposed for non-invasive quantification of diffuse interstitial fibrosis. We examined associations between T1 values and collagen volume fraction from endomyocardial b...
متن کاملPre-contrast T1 mapping for detection of myocardial fibrosis in asymptomatic and symptomatic aortic stenosis
Background Aortic stenosis (AS) leads to diffuse fibrosis in the myocardium which may impair cardiac function. Existing techniques (late gadolinium enhancement [LGE]) are not good at detecting diffuse, as opposed to focal, fibrosis. Pre-contrast T1-mapping may identify changes in the myocardium without the need for exogenous contrast, and our aim was to investigate its ability to detect diffuse...
متن کامل